Trials

Vaccine pandemic preparedness through Airway Immunology Characterization: A collaboration between the Novo-Nordisk Foundation and independent academic researchers. In this study, we will carry-out in-deepth characterization of the immunological differences in cellular and humoral responses following influenza vaccination administered either nasal or intramuscular routes in healthy individuals aged 18-49 years. Furthermore, we aim to identify immunological […]

The aim of this study is to determine if a time-updated, eosinophil-guided inhaled corticosteroid treatment in patients with severe and very severe COPD can lead to non-inferior treatment responses to standard treatment with combined ICS, LAMA and LABA, and whether the side-effects of ICS can be reduced by this guided administration. COPD: Eosinophil-guidedReduction of Inhaled([…)

A randomized, single-blinded clinical pilot study to assess whether vaccination with live attenuated vaccines can induce trained immunity and cause beneficial changes in patients with COPD (Gold stage B-E or FEV1 <30% of predicted).

We suggest investigating whether inhalation of the antibiotic levofloxacin is an alternative to systemic treatment for CAP in terms of treatment response, and at the same time reducing antimicrobial resistance and preserving the gut microbiome. We hypothesize that this reduces selection of resistant strains in the gut and reduces side-effects while preserving efficacy for treating […]